Pharmaceutical Synthetic Helper 2-MeTHF

2{{2}Methyltetrahydrofuran (2-MeTHF) ke mokelikeli o hlakileng o nang le monko oa ether{5}}o kang monko, o sebelisoang haholo joalo ka mokelikeli o khethehileng ho organic synthesis. E entsoe ka biomass e ka nchafatsoang, e fana ka mefuta e meng e bonolo ea tikoloho le e baballang chelete e ngata ho li-solvents tse tloaelehileng tse kang tetrahydrofuran (THF), diethyl ether, le dichloromethane. Ha e bapisoa le THF, 2-MeTHF e na le ntlha e belang e phahameng, chefo e tlase, le ho fokotseha ho hoholo ha metsi ka metsing, e leng se tlatsetsang ho ntlafatseng bokhoni ba ho ntša metsi le ho ntlafatsa ts'ebetso maemong a liindasteri le a laboratori. Thepa ea eona ea hydrophobic, hammoho le litšobotsi tse ntle tsa 'mele, e e etsa mokelikeli oa bohlokoa mekhoeng e tsitsitseng ea k'hemistri e tala.

2-MeTHF e ntse e sebelisoa haholo indastering ea meriana, haholo-holo ka har'a motsoako oa metsoako e sebetsang ea meriana (APIs) le lisebelisoa tse tala tse amanang le tsona. Bokhoni ba eona ba ho qhaqha ka mokhoa o nepahetseng mefuta e mengata ea metsoako ea manyolo, hammoho le boemo ba eona bo botala, bo tšehetsa mekhoa e tsitsitseng ea tlhahiso. Sena se etsa hore 2-MeTHF e be khetho e ratoang bakeng sa motsoako oa meriana moo ho amehang tikoloho le ho hlaphoheloa ha mokelikeli ho leng bohlokoa.

Lebitso la Sehlahiswa	Pharmaceutical synthetic helper 2-MeTHF|2-methyltetrahydrofuran CAS 96-47-9
CAS NO.	96-47-9
Mantsoe a sehlooho	2-Methyl tetrahydrofuran, 2-MeTHF bakeng sa meriana, Mothusi oa maiketsetso oa Litlhare 2-MeTHF
Foromo ea limolek'hule	C5H10O
Nomoro ea HS	2932190090
Foromo ea Sebopeho

1. Solvent bakeng sa Karabelo ea Organometallic

• Grignard Reagent Synthesis: 2-MeTHF ke sehlapolli sa maemo a holimo bakeng sa tšebetso ea Grignard ka lebaka la thepa ea eona e fokolang ea ho hokahanya, e matlafatsang tšebetso ea magnesium le ho matlafatsa lihlahisoa tsa reagent ho isa ho 98% (vs. 85% bakeng sa diethyl ether).
• Mamello ea Metsi: Ho fapana le THF kapa diethyl ether, e mamella trace water (Ka tlase kapa e lekanang le 0.1%) ntle le tahlehelo e kholo ea reactivity, ho fokotsa tlhokahalo ea maemo a feteletseng a anhydrous.

2. Ea Hare bakeng sa Lisebelisoa tsa Pharmaceutical (APIs)

• Lithethefatsi tse Thibelang Malaria: E bohlokoa bakeng sa ho kopanya chloroquine phosphate le primaquine phosphate, moo e sebetsang e le selelekela sa karabelo le sebopeho sa sebopeho.
• Vitamin B1 Synthesis: E sebetsa joalo ka sehlaseli le bohareng tlhahisong ea thiamine, e matlafatsa botsitso ba eona tlas'a maemo a asiti.

1. Ho sebetsana le Lintlha tsa Bohloko ba Indasteri

Likotsi Tsa Tšireletseho Lithakong Tsa Setso

Tharollo: 2-MeTHF e na le ntlha e phahameng ea ho belisa (degree ea 80) vs. THF (66 degree), e fokotsa ho hloka botsitso le ho chesa. BHT ea eona e tsitsitseng (150-400 ppm) e hatella sebopeho sa peroxide ka 90%, e fokotsa likotsi tsa ho phatloha nakong ea polokelo.

2. Theko e Theko e Felletseng ea Solvent

Tharollo: E etsa{0}}azeotrope e belang e tlase e nang le metsi (71℃), e nolofalletsang ho arohana ha bonolo ka distillation. Litefiso tsa ho hlaphoheloa li fihla ho 85% (vs. 50% bakeng sa diethyl ether), ho fokotsa litšila le litšenyehelo tsa ho hloekisa.

3. Khatello ea Taolo le ea Tikoloho

Tharollo: E nkiloe ho -based feedstocks (mohlala, furfural), e fokotsa carbon footprint ka 44% ha e bapisoa le solvents petroleum. E lumellana le REACH, ISO 14001, le melaoana ea k'hemistri e tala.

E tiisitsoe ka: 180kg Drum kapa 20mt ISO tanka

Haeba o hloka disampole kapa palo e nyane ea 2-Methyltetrahydrofuran (2-MeTHF), re fana ka likhetho tse fapaneng tsa ho paka ho lumellana le litlhoko tsa hau.